An epigenetic "LINK(RNA)" to pathological cardiac hypertrophy

Cell Metab. 2014 Oct 7;20(4):555-7. doi: 10.1016/j.cmet.2014.09.011.

Abstract

Reinduction of fetal gene expression is characteristic of the failing adult heart. Han et al. (2014) demonstrate that a novel cluster of long noncoding RNAs, Myheart, protects the heart from pathological hypertrophy, involving a negative-feedback molecular circuit with the epigenetic Brg1 complex to inhibit fetal-gene reactivation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cardiomegaly / genetics*
  • Cardiomegaly / pathology*
  • Humans
  • Myosin Heavy Chains / genetics*
  • RNA, Long Noncoding / genetics*

Substances

  • RNA, Long Noncoding
  • Myosin Heavy Chains