Platelets: still a therapeutical target for haemostatic disorders

Int J Mol Sci. 2014 Oct 7;15(10):17901-19. doi: 10.3390/ijms151017901.

Abstract

Platelets are cytoplasmatic fragments from bone marrow megakaryocytes present in blood. In this work, we review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and their potential as a target for designing new antithrombotic agents. The option of new biotechnological sources is also explored.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aspirin / pharmacology
  • Aspirin / therapeutic use
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism*
  • Hemostatic Disorders / metabolism
  • Hemostatic Disorders / pathology*
  • Humans
  • Integrins / genetics
  • Integrins / metabolism
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Aggregation Inhibitors / therapeutic use
  • Platelet Storage Pool Deficiency / metabolism
  • Platelet Storage Pool Deficiency / pathology
  • Thrombosis / drug therapy
  • Thrombosis / pathology

Substances

  • Integrins
  • Platelet Aggregation Inhibitors
  • Aspirin