Caught in the act: multiple binding sites for memantine

Stephan A Pless

doi:10.1016/j.str.2014.09.003

Caught in the act: multiple binding sites for memantine

Structure. 2014 Oct 7;22(10):1373-4. doi: 10.1016/j.str.2014.09.003.

Author

Stephan A Pless¹

Affiliation

¹ Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark. Electronic address: stephan.pless@sund.ku.dk.

PMID: 25295394
DOI: 10.1016/j.str.2014.09.003

Abstract

In this issue of Structure, Ulens and colleagues demonstrate how an elegant combination of complementary functional and structural approaches can uncover both binding sites and conformational consequences associated with the Alzheimer's drug memantine binding to an ion channel.

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MeSH terms

Animals
Humans
Ligand-Gated Ion Channels / chemistry*
Ligand-Gated Ion Channels / metabolism*
Memantine / chemistry*

Substances

Ligand-Gated Ion Channels
Memantine