Abstract
The alpha emitter Radium-223 ((22)3Ra-Cl2) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone refractory prostate cancer. More than 1,000 patients have been included in clinical phase I-III tests showing significant reduction in alkaline phosphatase- and PSA level and prolonged survival. Adverse events are usually mild to moderate and comprise gastrointestinal and myelotoxic symptoms. Intravenously administered (22)3Ra-Cl2 (half-life 11.4 days) will likely be given every four weeks for six treatments to out-patients.
MeSH terms
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / therapeutic use*
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Bone Density Conservation Agents / adverse effects
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Bone Density Conservation Agents / pharmacokinetics
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Bone Density Conservation Agents / therapeutic use*
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Bone Neoplasms / radiotherapy*
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Bone Neoplasms / secondary
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Humans
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Male
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Prostatic Neoplasms, Castration-Resistant / pathology
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Prostatic Neoplasms, Castration-Resistant / radiotherapy*
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Radioisotopes / adverse effects
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Radioisotopes / pharmacokinetics
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Radioisotopes / therapeutic use
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Radiometry
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Radium / adverse effects
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Radium / pharmacokinetics
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Radium / therapeutic use*
Substances
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Antineoplastic Agents
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Bone Density Conservation Agents
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Radioisotopes
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radium Ra 223 dichloride
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Radium