Genetic conflicts: stronger centromeres win tug-of-war in female meiosis

Benjamin D Ross; Harmit S Malik

doi:10.1016/j.cub.2014.08.053

Genetic conflicts: stronger centromeres win tug-of-war in female meiosis

Curr Biol. 2014 Oct 6;24(19):R966-8. doi: 10.1016/j.cub.2014.08.053.

Authors

Benjamin D Ross¹, Harmit S Malik²

Affiliations

¹ Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA; Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N. A2-025, Seattle, WA 98109, USA.
² Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N. A2-025, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N. A2-025, Seattle, WA 98109, USA. Electronic address: hsmalik@fhcrc.org.

PMID: 25291640
DOI: 10.1016/j.cub.2014.08.053

Abstract

Female meiosis presents unique opportunities for competition between chromosomes for evolutionary dominance. A new study reveals that centromere strength dictates meiotic success, driving karyotype evolution and reproductive isolation in mice.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Centromere / physiology*
Evolution, Molecular*
Female
Karyotype*
Meiosis*
Mice / genetics*

Abstract

Publication types

MeSH terms

Grants and funding