Visualization of monoamine oxidases in living cells using "Turn-ON" fluorescence resonance energy transfer probes

Analyst. 2014 Dec 7;139(23):6092-5. doi: 10.1039/c4an01195c.

Abstract

Novel FRET-based small molecule probes targeting monoamine oxidases (MAOs) were designed and synthesized. These "Turn-ON" fluorescent probes were proved to be capable of directly reporting MAO activities in live mammalian cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Fluorescence Resonance Energy Transfer / methods*
  • Fluorescent Dyes / chemistry*
  • Humans
  • Molecular Structure
  • Monoamine Oxidase / chemistry
  • Monoamine Oxidase / metabolism*

Substances

  • Fluorescent Dyes
  • Monoamine Oxidase