Autoimmune diseases: defects in immune specificity rather than a loss of suppressor cells

J G Knight

doi:10.1016/0167-5699(82)90015-9

Autoimmune diseases: defects in immune specificity rather than a loss of suppressor cells

Immunol Today. 1982 Dec;3(12):326-8. doi: 10.1016/0167-5699(82)90015-9.

Author

J G Knight¹

Affiliation

¹ MRC Autoimmunity Research Unit, University of Otago Medical School, PO Box 913, Dunedin, New Zealand.

PMID: 25290673
DOI: 10.1016/0167-5699(82)90015-9

Abstract

An argument that autoimmune responses arise not because immunoregulation is faulty but because somatic mutation in lymphocytes generates clones with autoreactive potential.