B-cell development

N R Klinman; D E Wylie; J M Teale

doi:10.1016/0167-5699(81)90049-9

B-cell development

Immunol Today. 1981 Nov;2(11):212-6. doi: 10.1016/0167-5699(81)90049-9.

Authors

N R Klinman¹, D E Wylie, J M Teale

Affiliation

¹ Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, CA. 92037, U.S.A.

PMID: 25290455
DOI: 10.1016/0167-5699(81)90049-9

Abstract

The B cell population represents an extremely complex set of cells with respect to the existence of funclional and developmental cell subpopulations and their extremely diverse repertoire of antibody specificities. This article summarizes the key features of the ontogeny and developmental stages of murine B cells, the subjects of a recent extensive review(1), and considers several crucial unresolved issues central to the ultimate understanding of B cell function and expression.