Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients

J Neuroimmunol. 2014 Dec 15;277(1-2):140-4. doi: 10.1016/j.jneuroim.2014.09.015. Epub 2014 Sep 28.

Abstract

Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-I, LGP2 and IFIH1 genes on MS risk.

Keywords: Association; Combinatorial effect; Multiple sclerosis; RIG-I-like receptors; RLRs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adult
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Germany
  • Humans
  • Interferon-Induced Helicase, IFIH1
  • Male
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • RNA Helicases / genetics
  • Receptors, Immunologic

Substances

  • Adaptor Proteins, Signal Transducing
  • MAVS protein, human
  • Receptors, Immunologic
  • DHX58 protein, human
  • RIGI protein, human
  • IFIH1 protein, human
  • DEAD Box Protein 58
  • DEAD-box RNA Helicases
  • Interferon-Induced Helicase, IFIH1
  • RNA Helicases