Abstract
Eight new clerodane diterpenes, balanspenes A-H (1-8), along with two known analogues (9 and 10), were isolated from the twigs of Casearia balansae. The structures of 1-8 were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of compounds 1, 4, and 7 were confirmed by comparing their experimental CD spectra with those calculated by the time-dependent density functional theory method. Compounds 4-7, 9, and 10 were found to possess the property of being able to stimulate NGF-mediated neurite outgrowth from PC12 cells.
MeSH terms
-
Animals
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Casearia / chemistry*
-
Circular Dichroism
-
Diterpenes, Clerodane / chemistry
-
Diterpenes, Clerodane / isolation & purification*
-
Diterpenes, Clerodane / pharmacology*
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology*
-
Molecular Structure
-
Nerve Growth Factor / pharmacology
-
Neurites / drug effects
-
Nuclear Magnetic Resonance, Biomolecular
-
PC12 Cells
-
Plant Stems / chemistry
-
Rats
Substances
-
Antineoplastic Agents, Phytogenic
-
Diterpenes, Clerodane
-
Drugs, Chinese Herbal
-
Nerve Growth Factor