Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles

Chem Commun (Camb). 2014 Nov 25;50(91):14249-52. doi: 10.1039/c4cc06929c.

Abstract

Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acylation
  • Catalysis
  • Decarboxylation
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Keto Acids / chemistry*
  • Molecular Structure
  • Palladium / chemistry*

Substances

  • Indoles
  • Keto Acids
  • Palladium
  • indoline