GTF2I-RARA is a novel fusion transcript in a t(7;17) variant of acute promyelocytic leukaemia with clinical resistance to retinoic acid

Br J Haematol. 2015 Mar;168(6):904-8. doi: 10.1111/bjh.13157. Epub 2014 Oct 4.
No abstract available

Keywords: GTF2I; RARA fusion gene; retinoic acid resistance; t(7; 17) translocation; variant acute promyelocytic leukaemia.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Antineoplastic Agents / therapeutic use
  • Base Sequence
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 7 / genetics
  • Drug Resistance, Neoplasm / genetics
  • Fatal Outcome
  • Humans
  • Karyotype
  • Leukemia, Promyelocytic, Acute / genetics*
  • Male
  • Molecular Sequence Data
  • Mutant Chimeric Proteins / genetics*
  • Neoplasm Proteins / genetics
  • Receptors, Retinoic Acid / genetics*
  • Retinoic Acid Receptor alpha
  • Transcription Factors, TFII / genetics*
  • Translocation, Genetic*
  • Tretinoin / therapeutic use

Substances

  • Antineoplastic Agents
  • GTF2I protein, human
  • Mutant Chimeric Proteins
  • Neoplasm Proteins
  • RARA protein, human
  • Receptors, Retinoic Acid
  • Retinoic Acid Receptor alpha
  • Transcription Factors, TFII
  • Tretinoin