Innate immune sensing of nucleic acids from mycobacteria

Microbes Infect. 2014 Dec;16(12):991-7. doi: 10.1016/j.micinf.2014.09.006. Epub 2014 Oct 2.

Abstract

Endosomal and cytosolic receptors engage recognition of mycobacterial-derived nucleic acids (MyNAs). In contrast, virulent mycobacteria may utilize nucleic acid recognition pathways to escape the host immune system. This short review will summarize the mechanisms by which MyNAs are sensed and how they influence host protective responses.

Keywords: Acid nucleics; Mycobacteria; Sensors; Tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA, Bacterial / immunology
  • Host-Pathogen Interactions*
  • Humans
  • Immune Evasion
  • Immunity, Innate / physiology*
  • Mycobacterium / genetics
  • Mycobacterium / immunology*
  • Mycobacterium Infections / immunology*
  • Mycobacterium Infections / metabolism
  • Nucleic Acids / immunology*
  • RNA, Bacterial / immunology
  • Signal Transduction

Substances

  • DNA, Bacterial
  • Nucleic Acids
  • RNA, Bacterial