Multicentric Castleman disease presenting with fever

J Pediatr. 2014 Dec;165(6):1261-5. doi: 10.1016/j.jpeds.2014.08.042. Epub 2014 Oct 1.

Abstract

Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder that usually manifests with nonspecific symptoms, including fever and lymphadenopathy. Treatment of pediatric MCD varies greatly. A 21-month-old child was diagnosed with MCD after presenting with fever. He had incomplete response to initial therapy directed at interleukin-6, but improved with subsequent chemotherapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Castleman Disease / diagnosis*
  • Castleman Disease / physiopathology
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / therapeutic use
  • Fever / drug therapy*
  • Fever / etiology
  • Humans
  • Infant
  • Interleukin-6 / metabolism
  • Lymph Nodes / pathology
  • Lymphocytes / pathology
  • Male
  • Pleural Effusion / drug therapy
  • Pleural Effusion / etiology
  • Prednisone / therapeutic use
  • Rituximab
  • Tomography, X-Ray Computed
  • Vincristine / therapeutic use

Substances

  • Antibodies, Monoclonal, Humanized
  • Antibodies, Monoclonal, Murine-Derived
  • Interleukin-6
  • R-CHOP protocol
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • tocilizumab
  • Prednisone

Supplementary concepts

  • Multi-centric Castleman's Disease