Improved cell activity on biodegradable photopolymer scaffolds using titanate nanotube coatings

Mater Sci Eng C Mater Biol Appl. 2014 Nov:44:38-43. doi: 10.1016/j.msec.2014.07.008. Epub 2014 Jul 9.

Abstract

The development of bioactive materials is in the premise of tissue engineering. For several years, surface functionalization of scaffolds has been one of the most promising approaches to stimulate cellular activity and finally improve implant success. Herein, we describe the development of a bioactive composite scaffold composed of a biodegradable photopolymer scaffold and titanate nanotubes (TNTs). The biodegradable photopolymer scaffolds were fabricated by applying mask-projection excimer laser photocuring at 308 nm. TNTs were synthesized and then spin-coated on the porous scaffolds. Upon culturing fibroblast cells on scaffolds, we found that nanotubes coating affects cell viability and proliferation demonstrating that TNT coatings enhance cell growth on the scaffolds by further improving their surface topography.

Keywords: Cell culturing; Excimer laser; Laser photocuring; Scaffolds; Tissue engineering; Titanate nanotubes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Animals
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Cells, Cultured
  • Coated Materials, Biocompatible / chemistry*
  • Mice
  • Microscopy, Electron, Transmission
  • Nanotubes / chemistry*
  • Polymers / chemistry*
  • Porosity
  • Tissue Engineering
  • Tissue Scaffolds / chemistry*
  • Titanium / chemistry*

Substances

  • Coated Materials, Biocompatible
  • Polymers
  • Titanium