A critical reflection on the technological development of deep brain stimulation (DBS)

Front Hum Neurosci. 2014 Sep 17:8:730. doi: 10.3389/fnhum.2014.00730. eCollection 2014.

Abstract

Since the translational research findings of Benabid and colleagues which partly led to their seminal paper regarding the treatment of mainly tremor-dominant Parkinson patients through thalamic high-frequency-stimulation (HFS) in 1987, we still struggle with identifying a satisfactory mechanistic explanation of the underlying principles of deep brain stimulation (DBS). Furthermore, the technological advance of DBS devices (electrodes and implantable pulse generators, IPG's) has shown a distinct lack of dynamic progression. In light of this we argue that it is time to leave the paleolithic age and enter hellenistic times: the device-manufacturing industry and the medical community together should put more emphasis on advancing the technology rather than resting on their laurels.

Keywords: deep brain stimulation; development; ethics; functional neurosurgery; innovation; stereotactic operation; technology.