Congenital fulminant Kaposiform hemangioendothelioma of the leg

Abstract

Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor associated with Kasabach Merritt syndrome. We present a case of congenital Kaposiform hemangioendothelioma of the leg in a female infant who was born to a mother treated with various medications including etanercept, a TNF antagonist, due to rheumatoid arthritis. The neonate suffered from a fulminant form of Kasabach Merritt syndrome with disseminated intravascular coagulation (DIC) resulting in multi-organ failure which led to her demise.

Keywords: Congenital; Etanercept; Kaposiform hemangioendothelioma; Kasabach Merritt syndrome; Multi-organ failure.