Abstract
A pair of racemic spirodienone neolignan enantiomers, (±)-sibiricumin A, were isolated from the extract of the fruits of Xanthium sibiricum. The resolution of (+)- and (-)-sibiricumin A was achieved by chiral HPLC. The absolute configurations of the racemes were assigned by X-ray and by electronic circular dichroism (ECD). This experiment is the first unambiguous determination of the absolute configuration of spirodienone neolignan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromatography, High Pressure Liquid
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Circular Dichroism
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Crystallography, X-Ray
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Leukocytes / drug effects
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Lignans / chemistry
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Lignans / isolation & purification*
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Lipopolysaccharides / pharmacology
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Molecular Conformation
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Molecular Structure
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Nitric Oxide / biosynthesis
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Rats
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Stereoisomerism
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Xanthium / chemistry*
Substances
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Lignans
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Lipopolysaccharides
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Spiro Compounds
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sibiricumin A
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Nitric Oxide