Increase of peripheral blood CD57+ T-cells in patients with oral squamous cell carcinoma

Anticancer Res. 2014 Oct;34(10):5729-34.

Abstract

Background/aim: The subset of T-cells positive for expression of cluster of differentiation (CD) 57 has been associated with various cancer phenotypes. However, the presence of CD57(+) T-cells in patients with oral squamous cell carcinoma (OSCC) has yet to be confirmed. In the present study, we examined the diagnostic significance of the presence of CD57(+) T-cells in peripheral blood (PB) from patients with OSCC.

Materials and methods: The subset of CD57(+) T-cells in PB was analyzed in 43 patients with OSCC by fluorescence-activated cell sorting (FACS) analysis.

Results: The proportion of CD57(+) T-cells, including both CD8(+) and CD4(+) subsets, significantly increased with clinical stage, especially in parallel with tumor size.

Conclusion: Our results suggest that an increase in the population of CD57(+) T-cells is a potent prognostic marker and may also influence the systemic immunity of patients with OSCC.

Keywords: CD57; Oral squamous cell carcinoma; T-cells; peripheral blood.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antigens, Surface / metabolism
  • CD57 Antigens / metabolism*
  • Carcinoma, Squamous Cell / blood*
  • Carcinoma, Squamous Cell / immunology
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Female
  • Flow Cytometry
  • Humans
  • Immunophenotyping
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Mouth Neoplasms / blood*
  • Mouth Neoplasms / immunology
  • Mouth Neoplasms / metabolism*
  • Mouth Neoplasms / pathology
  • Neoplasm Metastasis
  • Neoplasm Staging
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism*
  • Tumor Burden

Substances

  • Antigens, Surface
  • CD57 Antigens