Pollen Typhae total flavone improves insulin resistance in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats

Biosci Biotechnol Biochem. 2014;78(10):1738-42. doi: 10.1080/09168451.2014.930318. Epub 2014 Jun 26.

Abstract

Pollen Typhae total flavone (PTF), the extract from Pollen Typhae, is reported to enhance glucose uptake in C2C12 myotubes in vitro, but the convincing evidence is lacking in vivo. In this study, PTF ameliorated insulin resistance and dyslipidemia, but failed to significantly increase body weight in type 2 diabetic rats induced by high-fat diet and low-dose streptozotocin.

Keywords: dyslipidemia; glucose tolerance; insulin resistance; traditional Chinese medicine; type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / physiopathology
  • Diet, High-Fat / adverse effects*
  • Dose-Response Relationship, Drug
  • Eating / drug effects
  • Flavones / pharmacology*
  • Flavones / therapeutic use
  • Insulin Resistance*
  • Lipids / blood
  • Rats
  • Typhaceae / chemistry*

Substances

  • Flavones
  • Lipids
  • flavone