IL-25: the missing link between allergy, viral infection, and asthma?

Evangelos Andreakos; Nikolaos G Papadopoulos

doi:10.1126/scitranslmed.3010273

IL-25: the missing link between allergy, viral infection, and asthma?

Sci Transl Med. 2014 Oct 1;6(256):256fs38. doi: 10.1126/scitranslmed.3010273.

Authors

Evangelos Andreakos¹, Nikolaos G Papadopoulos²

Affiliations

¹ Department of Immunology, Center for Clinical and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece. vandreakos@bioacademy.gr.
² Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children's Hospital, University of Manchester, Manchester M13 9WL, UK. Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou," University of Athens, Athens 11527, Greece.

PMID: 25273094
DOI: 10.1126/scitranslmed.3010273

Abstract

Interleukin 25 boosts proinflammatory and proasthmatic responses in the allergic lung and emerges as a key determinant of virally induced asthma exacerbations and as a therapeutic target for asthma (Beale et al., this issue).

Publication types

Comment

MeSH terms

Asthma / physiopathology*
Humans
Hypersensitivity / physiopathology*
Interleukin-17 / biosynthesis*
Pneumonia, Viral / immunology*
Rhinovirus / physiology*

Substances

Interleukin-17