The purpose of the present study was to investigate the effect of the composition of experimental fluorinated soft lining materials on bond strength to denture base resin. Vinylidene fluoride/hexafluoro propylene copolymer (2-6F), tridecafluorooctyl methacrylate (13FMA), methoxy diethylene glycol methacrylate (MDGMA), and silica (as filler) were used for fabrication of the experimental soft lining materials. Nine experimental soft lining materials having various compositions of 2-6F, 13FMA, and MDGMA were prepared. Shear and tensile bond strength tests were performed before and after immersion in water. The water sorption for the materials was also measured. An increase in the content of acrylic monomer, MDGMA, in the experimental materials increased the bond strength before immersion in water but reduced the bond strength after immersion in water as compared to that before immersion in water. The inclusion of fluorinated monomer (13FMA) in the materials appeared to affect water sorption.