The present contribution is focused on the evolution and current trends of comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS), with respect to a review that described this specific methodology published at the beginning of 2008 (Mondello et al., 2008). In fact, since then there has been considerable evolution in the MS field, certainly exceeding that observed in GC × GC. In particular, the present paper will cover the combination of novel MS machines [single quadrupole (Q) and triple quadrupole, isotope ratio, low- and high-resolution time-of-flight (ToF), hybrid (Q-ToF)] to GC × GC systems, and will position comprehensive two-dimensional gas chromatography within the wider context of separation science. © 2014 Wiley Periodicals, Inc. Mass Spec Rev 35:524-534, 2016.
Keywords: comprehensive two-dimensional gas chromatography; high resolution mass spectrometry; quadrupole mass spectrometry; tandem mass spectrometry; time-of-flight mass spectrometry.
© 2014 Wiley Periodicals, Inc.