Abstract
The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified Ni(II) Schiff base complex as the key step.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Amino Acids / chemistry*
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Catalysis
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Cations, Divalent
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Crystallography, X-Ray
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Fluorine / chemistry*
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Halogenation
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Molecular Mimicry
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Nickel / chemistry*
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Peptides / chemical synthesis*
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Peptidomimetics / chemical synthesis*
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Protein Structure, Secondary
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Schiff Bases / chemistry*
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Stereoisomerism
Substances
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Amino Acids
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Cations, Divalent
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Peptides
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Peptidomimetics
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Schiff Bases
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Fluorine
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Nickel