Abstract
To discover new bioactive lead compounds for medicinal purposes, herein, (E)-3-(substituted amino)-1-thiophen-2-yl-prop-2-en-1-ones 3-8, aminopyridines 9-11, benzylamine 12, nicotinamide 13, pyrimidines 14, 15, hexanoic acid 16 and triazolopyrimidine 19 were prepared and tested for cytotoxic activity. Results showed that the tested compounds exhibited a remarkable activity, especially compounds 3 and 19 with IC50 values (55.2 and 50.49 microM, respectively) compared to doxorubicin (IC50 = 71.8 microM) as a reference drug.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminopyridines / chemical synthesis*
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Aminopyridines / pharmacology
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Aniline Compounds / chemical synthesis*
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Aniline Compounds / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Benzylamines / chemical synthesis*
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Benzylamines / pharmacology
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Design*
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Female
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Humans
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Inhibitory Concentration 50
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MCF-7 Cells
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Molecular Structure
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Niacinamide / analogs & derivatives
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Niacinamide / chemical synthesis*
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Niacinamide / pharmacology
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Structure-Activity Relationship
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
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Triazoles / chemical synthesis*
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Triazoles / pharmacology
Substances
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Aminopyridines
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Aniline Compounds
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Antineoplastic Agents
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Benzylamines
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Pyrimidines
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Thiophenes
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Triazoles
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Niacinamide