HCV NS5A inhibitors disrupt replication factory formation: a novel mechanism of antiviral action

Gastroenterology. 2014 Nov;147(5):959-62. doi: 10.1053/j.gastro.2014.09.024. Epub 2014 Sep 27.

Authors

Nicholas S Eyre¹, Michael R Beard²

Affiliations

¹ School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia; Centre for Cancer Biology, Adelaide, Australia.
² School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia; Centre for Cancer Biology, Adelaide, Australia. Electronic address: michael.beard@adelaide.edu.au.

PMID: 25265576
DOI: 10.1053/j.gastro.2014.09.024

No abstract available

Publication types

Editorial
Comment

MeSH terms

Antiviral Agents / pharmacology*
Carbamates
Cell Membrane / drug effects*
Hepacivirus / drug effects*
Hepatocytes / drug effects*
Humans
Imidazoles / pharmacology*
Protease Inhibitors / pharmacology*
Pyrrolidines
Valine / analogs & derivatives
Viral Nonstructural Proteins / antagonists & inhibitors*
Virus Replication / drug effects*

Substances

Antiviral Agents
Carbamates
Imidazoles
Protease Inhibitors
Pyrrolidines
Viral Nonstructural Proteins
NS-5 protein, hepatitis C virus
Valine
daclatasvir