Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu

Chin J Nat Med. 2014 Sep;12(9):685-8. doi: 10.1016/S1875-5364(14)60104-7.

Abstract

Aim: To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill.

Method: Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported.

Results: Three mycophenolic acid derivatives, 6-((2E, 6E)-3, 7-dimethyldeca-2, 6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (1), 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-5, 7-dihydroxy-4-methylphtanlan-1-one (2), and 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (3) were isolated.

Conclusion: Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with IC50 values of 39.1, 31.1, 27.4, and 35.7 μmol·L(-1), respectively.

Keywords: Cytotoxicity; Laetiporus sulphureus; Mycophenolic acid derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales
  • Biological Products / chemistry
  • Biological Products / isolation & purification*
  • Biological Products / pharmacology
  • Biological Products / therapeutic use
  • HL-60 Cells
  • Humans
  • MCF-7 Cells
  • Molecular Structure
  • Mycophenolic Acid / analogs & derivatives*
  • Mycophenolic Acid / chemistry
  • Mycophenolic Acid / isolation & purification
  • Neoplasms / drug therapy
  • Phenols / chemistry
  • Phenols / isolation & purification*
  • Phenols / pharmacology
  • Phenols / therapeutic use
  • Polyporales / chemistry*

Substances

  • 6-((2E,6E)-3,7,11-trimethyldedoca-2,6,10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one
  • 6-((2E,6E)-3,7-dimethyldeca-2,6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one
  • Biological Products
  • Phenols
  • Mycophenolic Acid