Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21

FEBS Lett. 2014 Nov 3;588(21):4026-31. doi: 10.1016/j.febslet.2014.09.022. Epub 2014 Sep 27.

Abstract

Translationally-controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation. Previous observations of a twofold induction of TCTP mRNA during osteoclast differentiation prompted us to investigate its involvement in osteoclast differentiation. The osteoclastogenicity of TCTP gradually expressed during osteoclast differentiation was confirmed in mouse and human cells using loss-of-function studies and TCTP heterogeneous mice and transgenic mice. Higher expression ratios of TCTP to p21 could represent TCTP-mediated phenotypic induction of osteoclast differentiation accompanied by p21 down-regulation, attenuating the proliferation of osteoclast precursor cells.

Keywords: Bone; Osteoclast; Proliferation; TCTP; p21.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers, Tumor / deficiency
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Bone Density
  • Cell Count
  • Cell Differentiation*
  • Cell Proliferation
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism*
  • Gene Knockdown Techniques
  • Humans
  • Male
  • Mice
  • Mice, Transgenic
  • Osteoclasts / cytology*
  • Osteoclasts / metabolism
  • Tumor Protein, Translationally-Controlled 1

Substances

  • Biomarkers, Tumor
  • Cyclin-Dependent Kinase Inhibitor p21
  • TPT1 protein, human
  • Tpt1 protein, mouse
  • Tumor Protein, Translationally-Controlled 1