Biogenesis of Circular RNAs

Cell. 2014 Sep 25;159(1):13-14. doi: 10.1016/j.cell.2014.09.005.

Abstract

Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences. Both papers show that several types of circular RNA transcripts can be produced from a single gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Drosophila / genetics*
  • Humans
  • RNA / biosynthesis*
  • RNA Precursors / metabolism*
  • RNA Splicing*
  • RNA, Messenger / metabolism*

Substances

  • RNA Precursors
  • RNA, Messenger
  • RNA