AML cells carrying NPM1 mutation are resistant to nucleophosmin displacement from nucleoli caused by the G-quadruplex ligand TmPyP4

Cell Death Dis. 2014 Sep 25;5(9):e1427. doi: 10.1038/cddis.2014.402.
No abstract available

Publication types

  • Letter

MeSH terms

  • Cell Death / drug effects
  • Cell Line, Tumor
  • Cell Nucleolus / metabolism*
  • G-Quadruplexes* / drug effects
  • Humans
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / metabolism
  • Mutation*
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Nucleophosmin
  • Porphyrins / pharmacology*
  • Protein Transport / drug effects
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • NPM1 protein, human
  • Nuclear Proteins
  • Porphyrins
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Nucleophosmin
  • tetra(4-N-methylpyridyl)porphine