Prevalence of chromosomally integrated human herpesvirus 6 in patients with human herpesvirus 6-central nervous system dysfunction

Biol Blood Marrow Transplant. 2015 Feb;21(2):371-3. doi: 10.1016/j.bbmt.2014.09.015. Epub 2014 Sep 22.

Abstract

We identified 37 hematopoietic cell transplantation recipients with human herpesvirus 6 (HHV-6) central nervous system dysfunction and tested donor-recipient pairs for chromosomally integrated HHV-6 (ciHHV-6). One patient had ciHHV-6A with possible HHV-6A reactivation and encephalitis. There was no ciHHV-6 enrichment in this group, but larger studies are needed to determine if patients with ciHHV-6 are at increased risk for HHV-6-associated diseases or other complications.

Keywords: Central nervous system (CNS); Herpesvirus (hhv-6); Integration; Transplant.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Central Nervous System / metabolism
  • Central Nervous System / pathology
  • Central Nervous System / virology
  • Chromosomes, Human / chemistry
  • Chromosomes, Human / virology*
  • DNA, Viral / cerebrospinal fluid*
  • Encephalitis, Viral / cerebrospinal fluid
  • Encephalitis, Viral / genetics
  • Encephalitis, Viral / pathology
  • Encephalitis, Viral / virology*
  • Hematopoietic Stem Cell Transplantation
  • Herpesvirus 6, Human / classification
  • Herpesvirus 6, Human / genetics*
  • Herpesvirus 6, Human / isolation & purification
  • Humans
  • Molecular Typing
  • Phylogeny
  • Roseolovirus Infections / cerebrospinal fluid
  • Roseolovirus Infections / genetics
  • Roseolovirus Infections / pathology
  • Roseolovirus Infections / virology*
  • Transplantation, Homologous
  • Virus Activation
  • Virus Integration*

Substances

  • DNA, Viral