A cytotoxic and cytostatic gold(III) corrole

Chem Commun (Camb). 2014 Nov 18;50(89):13789-92. doi: 10.1039/c4cc06577h.

Abstract

We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cytostatic Agents / chemistry
  • Cytostatic Agents / pharmacology
  • Cytotoxins / chemistry
  • Cytotoxins / pharmacology
  • Gallium / chemistry
  • Gallium / pharmacology
  • Gold* / chemistry
  • Gold* / pharmacology
  • Humans
  • Organogold Compounds* / chemistry
  • Organogold Compounds* / pharmacology
  • Porphyrins* / chemistry
  • Porphyrins* / pharmacology
  • Serum Albumin / chemistry
  • Serum Albumin / metabolism

Substances

  • Antineoplastic Agents
  • Cytostatic Agents
  • Cytotoxins
  • Organogold Compounds
  • Porphyrins
  • Serum Albumin
  • corrole
  • Gold
  • Gallium