Synthesis of dihydrobenzoheterocycles through Al(OTf)3-mediated cascade cyclization and ionic hydrogenation

Yulin Tian; Xiaojian Wang; Qiong Xiao; Chenbin Sun; Dali Yin

doi:10.1021/jo501824z

Synthesis of dihydrobenzoheterocycles through Al(OTf)3-mediated cascade cyclization and ionic hydrogenation

J Org Chem. 2014 Oct 17;79(20):9678-85. doi: 10.1021/jo501824z. Epub 2014 Oct 2.

Authors

Yulin Tian¹, Xiaojian Wang, Qiong Xiao, Chenbin Sun, Dali Yin

Affiliation

¹ State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, and ‡Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing 100050, P. R. China.

PMID: 25251644
DOI: 10.1021/jo501824z

Abstract

A facile and versatile synthesis of dihydrobenzoheterocycles via Al(OTf)3-mediated cascade cyclization and ionic hydrogenation has been developed. The reaction is applicable to a wide range of substrates with various functional groups to afford the corresponding products in good yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclization
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / chemistry*
Hydrogenation
Mesylates / chemistry*
Molecular Structure

Substances

Heterocyclic Compounds
Mesylates
trifluoromethanesulfonic acid