Lung cancer is considered a kind of malignant tumors of the world highest incidence. As it is not sensitive to chemotherapy and easy to produce drug resistance, improving effect of anticancer drug becomes a research focus recent years. siRNA, small interfering RNA, can silence complemenary mRNA which is a kind of gene therapy. Target peptides are small molecular peptides which specifically bind to tumor surface materials. When used with siRNA, target peptides can increase accumulation of siRNA in tumor cells and enhance the silencing effect. As result, drug resistance of lung cancer reduced and the effect of therapy can be improved. This method provides new direction and strategy for targeted therapy of lung cancer. This article will make a brief overview of target peptides applying in siRNA dilivery for the research of lung cancer treatment.
肺癌被认为是全球发病率最高的一种恶性肿瘤，其对化疗药物不敏感且易产生耐药性，因此增强肺癌药物治疗效果是近年来研究的热点。siRNA是一种小RNA分子，可以沉默与之互补的目标mRNA，是一种基因治疗手段。靶向肽是一类小分子多肽，它可以与siRNA联合使用，利用其与肿瘤表面物质特异性结合发挥靶向作用。联合靶向肽的特异性和siRNA的治疗作用，增加siRNA在靶点位置的聚集，增强沉默效果，可以提高肺癌对药物的敏感性并降低耐药作用，进而增强肺癌治疗效果，为肺癌的靶向治疗提供新的方向和策略。本文将对靶向肽在递送siRNA进行肺癌治疗研究中的应用作一简要综述。