In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

Moritz Nazarenus; Qian Zhang; Mahmoud G Soliman; Pablo Del Pino; Beatriz Pelaz; Susana Carregal-Romero; Joanna Rejman; Barbara Rothen-Rutishauser; Martin J D Clift; Reinhard Zellner; G Ulrich Nienhaus; James B Delehanty; Igor L Medintz; Wolfgang J Parak

doi:10.3762/bjnano.5.161

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

Beilstein J Nanotechnol. 2014 Sep 9:5:1477-90. doi: 10.3762/bjnano.5.161. eCollection 2014.

Affiliations

¹ Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany.
² CIC Biomagune, Paseo Miramón 182, 20009 San Sebastian, Spain.
³ BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Route de L'ancienne Papeterie CP 209, Marly 1, 1723, Fribourg, Switzerland.
⁴ Institute of Physical Chemistry, University of Duisburg-Essen, Universitätsstraße 5, 45141 Essen, Germany.
⁵ Institute of Applied Physics and Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Straße 1, 76131 Karlsruhe, Germany ; Department of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, IL 61801, USA.
⁶ Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, 4555 Overlook Avenue Southwest, Washington D.C., 20375, USA.
⁷ Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany ; CIC Biomagune, Paseo Miramón 182, 20009 San Sebastian, Spain.

Abstract

The interfacing of colloidal nanoparticles with mammalian cells is now well into its second decade. In this review our goal is to highlight the more generally accepted concepts that we have gleaned from nearly twenty years of research. While details of these complex interactions strongly depend, amongst others, upon the specific properties of the nanoparticles used, the cell type, and their environmental conditions, a number of fundamental principles exist, which are outlined in this review.

Keywords: colloidal stability; intracellular particle distribution; nanoparticles; protein corona; toxicity of nanoparticles.

Publication types

Review