Preparation TiO2 core-shell nanospheres and application as efficiency drug detection sensor

Jingli Yue; Zhenhua Chen; Yifeng E; Lianshan Chen; Jing Zhang; Yimeng Song; Yuchun Zhai

doi:10.1186/1556-276X-9-465

Preparation TiO2 core-shell nanospheres and application as efficiency drug detection sensor

Nanoscale Res Lett. 2014 Sep 3;9(1):465. doi: 10.1186/1556-276X-9-465. eCollection 2014.

Authors

Jingli Yue¹, Zhenhua Chen², Yifeng E², Lianshan Chen¹, Jing Zhang², Yimeng Song³, Yuchun Zhai⁴

Affiliations

¹ School of Material and Metallurgy, Northeastern University, 110004 Shenyang, People's Republic of China ; College of Pharmacy, Liaoning Medical University, 121001 Jinzhou, People's Republic of China.
² College of Pharmacy, Liaoning Medical University, 121001 Jinzhou, People's Republic of China.
³ College of Chemistry, Nankai University, 300071 Tianjin, People's Republic of China.
⁴ School of Material and Metallurgy, Northeastern University, 110004 Shenyang, People's Republic of China.

Abstract

In this paper, we report the facile preparation of monodisperse titanium dioxide-diltiazem/tetrachlorobismuth core-shell nanospheres (TiO2@DTMBi), in which, diltiazem (DTM)/tetrachlorobismuth (BiCl4) complexes were employed as electroactive materials. The morphology, size, formation, and structure of the obtained TiO2@DTMBi spheres were investigated by transmission electron microscopy, scanning electron microscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and X-ray diffraction. The optimal condition of obtained monodisperse 40-nm TiO2@DTMBi spheres was researched. The results of using TiO2@DTMBi nanospheres as proposed drug sensor indicate a wide linear range (10(-7) to 10(-1) M) and a very low detection limit of 0.20 μg/mL.

Keywords: Diltiazem hydrochloride; Nanoparticles; Sensors; Titanium dioxide.