Abstract
Tissue-specific NK cell subpopulations are found in adult gut, liver, and endometrium, as well as other sites in the body. Some differ phenotypically and functionally from pbNK cells, and their origin is disputed. In this review, we discuss tissue-specific NK cells and suggest that subpopulations differentiate in situ from tissue-resident hematopoietic progenitor cells. The understanding of the origins and maturation requirements of tissue-specific NK cells could lead to new classes of immunotherapy for organ-specific pathologies of infectious and malignant origin.
Keywords:
hematopoietic progenitors; innate immunity; lymphoid cells; natural killer cell progenitors.
© 2014 Society for Leukocyte Biology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Degranulation
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Cell Lineage
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Cellular Microenvironment
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Chemotaxis
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Cytokines / metabolism
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Cytotoxicity, Immunologic
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Digestive System / immunology
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Female
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Histocompatibility Antigens Class I / immunology
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Humans
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Immunologic Memory
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Immunologic Surveillance / immunology*
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Immunophenotyping
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Killer Cells, Natural / classification
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Killer Cells, Natural / cytology
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / metabolism
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Lung / immunology
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Lymphopoiesis
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Male
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Mice
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Models, Immunological
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Organ Specificity
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Pregnancy
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Receptors, KIR / immunology
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Uterus / immunology
Substances
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Cytokines
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Histocompatibility Antigens Class I
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Receptors, KIR