Abstract
bla(NDM-)5 was found in Escherichia coli strain 0215 from a Chinese patient without travel history. Genomic sequencing and conjugation experiments were performed. Strain 0215 belonged to sequence type 167 (ST167) and had other resistance determinants, including bla(TEM-135), bla(CTX-M-14), and aac(6')-Ib. bla(NDM-5) was carried by a 47-kb self-transmissible IncX3 plasmid and was in a complex genetic context similar to that of bla(NDM-1) on IncX3 plasmids. IncX3 plasmids might have emerged as a common vehicle mediating the spread of bla(NDM).
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Anti-Bacterial Agents / pharmacology
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Asian People
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Conjugation, Genetic
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Drug Resistance, Bacterial / genetics*
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli / genetics*
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Escherichia coli / growth & development
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Escherichia coli Infections / diagnosis
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Escherichia coli Infections / microbiology
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Genome, Bacterial*
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Genotype
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Humans
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Male
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Plasmids / chemistry*
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Plasmids / metabolism
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Sequence Analysis, DNA
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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beta-Lactams
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beta-Lactamases