Primary Epstein-Barr virus infection and probable parvovirus B19 reactivation resulting in fulminant hepatitis and fulfilling five of eight criteria for hemophagocytic lymphohistiocytosis

Int J Infect Dis. 2014 Nov:28:143-6. doi: 10.1016/j.ijid.2014.08.003. Epub 2014 Sep 19.

Abstract

A case of primary Epstein-Barr virus (EBV) infection/parvovirus B19 reactivation fulfilling five of eight criteria for hemophagocytic lymphohistiocytosis (HLH) is presented. Despite two coinciding viral infections, massive splenomegaly, and fulminant hepatitis, the patient had a good clinical outcome, probably due to an early onset form of HLH with normal leukocyte count, normal natural killer (NK) cell function, and a lack of hemophagocytosis.

Keywords: Epstein–Barr virus; Hemophagocytic lymphohistiocytosis; Parvovirus B19.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Coinfection / diagnosis*
  • Epstein-Barr Virus Infections / diagnosis*
  • Hepatitis / virology*
  • Humans
  • Lymphohistiocytosis, Hemophagocytic / diagnosis*
  • Lymphohistiocytosis, Hemophagocytic / virology
  • Male
  • Parvoviridae Infections / diagnosis*
  • Parvovirus B19, Human* / isolation & purification