Phosphoinositides and host-pathogen interactions

Biochim Biophys Acta. 2015 Jun;1851(6):911-8. doi: 10.1016/j.bbalip.2014.09.011. Epub 2014 Sep 19.

Abstract

Phosphoinositides control key cellular processes including vesicular trafficking and actin polymerization. Intracellular bacterial pathogens manipulate phosphoinositide metabolism in order to promote their uptake by target cells and to direct in some cases the biogenesis of their replication compartments. In this chapter, we review the molecular strategies that major pathogens including Listeria, Mycobacterium, Shigella, Salmonella, Legionella and Yersinia use to hijack phosphoinositides during infection. This article is part of a Special Issue entitled Phosphoinositides.

Keywords: Cytoskeleton; Legionella; Listeria; Mycobacteria; Salmonella; Shigella; Yersinia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Actin Cytoskeleton / ultrastructure
  • Bacterial Infections / immunology
  • Bacterial Infections / metabolism*
  • Bacterial Infections / microbiology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / immunology
  • Bacterial Proteins / metabolism*
  • Gene Expression
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Legionella / immunology
  • Legionella / metabolism
  • Listeria / immunology
  • Listeria / metabolism
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / metabolism
  • Phosphatidylinositols / immunology
  • Phosphatidylinositols / metabolism*
  • Protein Binding
  • Salmonella / immunology
  • Salmonella / metabolism
  • Shigella / immunology
  • Shigella / metabolism
  • Transport Vesicles / metabolism
  • Yersinia / immunology
  • Yersinia / metabolism

Substances

  • Bacterial Proteins
  • Phosphatidylinositols