Objective: To determine the prevalence of saliva Helicobacter pylori in Lanzhou and investigate Helicobacter pylori-related diseases.
Methods: Helicobacter pylori was detected through bacterial culture, Gram stain microscopy, and urease test from saliva samples collected from 941 residents of Lanzhou. The infection rate and growth of Helicobacter pylori among the residents were analyzed in terms of different oral health conditions, oral disease, gender, urban and rural status, and age.
Results: The rate of Helicobacter pylori-positive saliva in Lanzhou was 42.72%. The status of Helicobacter pylori infection showed significant difference among subjects with different oral hygiene and oral diseases. The rate of Helicobacter pylori-positive saliva among females was 47.89%, which was greater compared with the rate among males (38.45%, P = 0.004, chi2 = 8.492). The rate of Helicobacter pylori-positive saliva in the town was 33.99%, which was less than the rate for the villages (50.93%, P = 0.000, chi2 = 27.551). The rate of Helicobacter pylori-positive saliva among residents aged 10 to 59 showed a flat trend with no significant differences. However, the rate of Helicobacter pylori-positive saliva among residents over 60 years old showed a significant increase. No significant difference was found in the growth of saliva Helicobacter pylori (P = 0.086).
Conclusion: The rate of Helicobacter pylori-positive saliva is related to the subjects' oral hygiene, oral disease, gender, age, and living conditions.
目的: 分析兰州地区人群唾液幽门螺杆菌的感染状况，为防治幽门螺杆菌提供科学依据。
方法: 收集兰州地区941例患者的唾液标本进行幽门螺杆菌的细菌学培养，并进行革兰染色镜检及生化特性鉴定。对不同口腔卫生情况、口腔疾病、性别、城乡、年龄段患者的唾液幽门螺杆菌感染率及生长情况进行分析。
结果: 兰州地区人群唾液幽门螺杆菌的阳性率为42.72%。不同口腔卫生和口腔疾病情况下，患者唾液幽门螺杆菌的阳性率均存在统计学差异（P<0.05）。男性与女性的唾液幽门螺杆菌阳性率分别为38.45%、47.89%，女性阳性率高于男性（P=0.004，χ2=8.492）；城市、农村人群的唾液幽门螺杆菌阳性率分别为33.99%、50.93%，农村人群的阳性率高于城市人群（P=0.000，χ2=27.551）。10~59岁各年龄段唾液幽门螺杆菌阳性率基本上变化不大，呈平坦趋势，60岁之后呈上升趋势。不同年龄段唾液幽门螺杆菌生长量无统计学差异（P=0.086）。
结论: 兰州地区人群的唾液幽门螺杆菌阳性率与其口腔卫生、口腔疾病、性别、年龄及生活环境等均相关。