Corticosteroid use in small animal neurology

Vet Clin North Am Small Anim Pract. 2014 Nov;44(6):1059-74. doi: 10.1016/j.cvsm.2014.07.004. Epub 2014 Sep 18.

Abstract

Glucocorticoid drugs are frequently used nonspecifically by veterinarians to control clinical signs associated with central nervous system disease. However, this use is infrequently justified and can also be associated with detrimental long-term patient outcomes. First, there are few diseases for which glucocorticoids are the preferred or definitive treatment. Second, their actions may blunt subsequent diagnostic efforts, for instance, by altering MRI appearance or cerebrospinal fluid cell content, or lead owners to abandon pursuit of more appropriate therapies if they perceive the first-line steroid therapy to be a failure.

Keywords: Dog; Glucocorticoid; Immunosuppression; Inflammation; Intracranial pressure; Meningoencephalomyelitis; Tumor.

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / therapeutic use
  • Central Nervous System Diseases / drug therapy
  • Central Nervous System Diseases / veterinary*
  • Dog Diseases / drug therapy*
  • Dogs
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use

Substances

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Immunosuppressive Agents