The interplay between antiviral immunity and allo-immune reactivity after renal transplantation: consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR)

Transpl Immunol. 2014 Oct;31(4):191-4. doi: 10.1016/j.trim.2014.09.004. Epub 2014 Sep 17.

Abstract

In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.

Keywords: Alloresponse; BKV; CMV; Cross-reactivity; Heterologous immunity; Renal transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / therapeutic use
  • BK Virus / immunology
  • Cross Reactions / immunology*
  • Cytomegalovirus / immunology
  • Cytomegalovirus Infections / immunology*
  • Graft Rejection / immunology
  • Humans
  • Immunosuppression Therapy / methods
  • Immunosuppressive Agents / therapeutic use
  • Isoantigens / immunology*
  • Kidney / virology
  • Kidney Transplantation / adverse effects*
  • Netherlands
  • Polyomavirus Infections / immunology*
  • Transplantation, Homologous

Substances

  • Antiviral Agents
  • Immunosuppressive Agents
  • Isoantigens