Computer-aided design of the human aortic root

E A Ovcharenko; K U Klyshnikov; A R Vlad; I N Sizova; A N Kokov; D V Nushtaev; A E Yuzhalin; I U Zhuravleva

doi:10.1016/j.compbiomed.2014.08.023

Computer-aided design of the human aortic root

Comput Biol Med. 2014 Nov:54:109-15. doi: 10.1016/j.compbiomed.2014.08.023. Epub 2014 Sep 1.

Authors

E A Ovcharenko¹, K U Klyshnikov², A R Vlad¹, I N Sizova¹, A N Kokov¹, D V Nushtaev³, A E Yuzhalin⁴, I U Zhuravleva¹

Affiliations

¹ Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
² Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation. Electronic address: KlyshnikovK@gmail.com.
³ "TESIS" Limited Liability Company, Moscow, Russian Federation.
⁴ Department of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

PMID: 25238567
DOI: 10.1016/j.compbiomed.2014.08.023

Abstract

The development of computer-based 3D models of the aortic root is one of the most important problems in constructing the prostheses for transcatheter aortic valve implantation. In the current study, we analyzed data from 117 patients with and without aortic valve disease and computed tomography data from 20 patients without aortic valvular diseases in order to estimate the average values of the diameter of the aortic annulus and other aortic root parameters. Based on these data, we developed a 3D model of human aortic root with unique geometry. Furthermore, in this study we show that by applying different material properties to the aortic annulus zone in our model, we can significantly improve the quality of the results of finite element analysis. To summarize, here we present four 3D models of human aortic root with unique geometry based on computational analysis of ECHO and CT data. We suggest that our models can be utilized for the development of better prostheses for transcatheter aortic valve implantation.

Keywords: 3D modeling; Aortic root; Computed tomography; Echocardiography; Finite element analysis.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Aorta / diagnostic imaging
Aorta / physiopathology*
Aorta / surgery
Aortic Valve / diagnostic imaging
Aortic Valve / physiopathology*
Aortic Valve / surgery
Bicuspid Aortic Valve Disease
Compressive Strength
Computer Simulation
Computer-Aided Design*
Elastic Modulus
Female
Heart Defects, Congenital / diagnostic imaging
Heart Defects, Congenital / physiopathology*
Heart Defects, Congenital / surgery
Heart Valve Diseases / diagnostic imaging
Heart Valve Diseases / physiopathology*
Heart Valve Diseases / surgery
Heart Valve Prosthesis*
Humans
Male
Middle Aged
Models, Cardiovascular*
Prosthesis Design
Prosthesis Fitting / methods
Shear Strength
Stress, Mechanical
Tensile Strength
Transcatheter Aortic Valve Replacement / instrumentation*
Transcatheter Aortic Valve Replacement / methods
Ultrasonography
Young Adult