A novel synthesis of the oxazolidinone antithrombotic agent rivaroxaban

Molecules. 2014 Sep 18;19(9):14999-5004. doi: 10.3390/molecules190914999.

Abstract

A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step. The synthetic route represents a convenient procedure for the production of rivaroxaban.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Factor Xa Inhibitors / chemical synthesis*
  • Factor Xa Inhibitors / pharmacology
  • Morpholines / chemical synthesis*
  • Morpholines / pharmacology
  • Proton Magnetic Resonance Spectroscopy
  • Rivaroxaban
  • Thiophenes / chemical synthesis*
  • Thiophenes / pharmacology

Substances

  • Factor Xa Inhibitors
  • Morpholines
  • Thiophenes
  • Rivaroxaban