Abstract
Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Anxiety Agents / administration & dosage
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Anti-Anxiety Agents / chemistry*
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Anti-Anxiety Agents / isolation & purification
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Anxiety / drug therapy
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Humans
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Magnoliopsida / chemistry*
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Male
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Mice
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Phenanthrenes / administration & dosage
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Phenanthrenes / chemistry*
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Phenanthrenes / isolation & purification
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
Substances
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Anti-Anxiety Agents
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Phenanthrenes
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Plant Extracts
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phenanthrene