First report of Westerdykella dispersa as a cause of an angioinvasive fungal infection in a neutropenic host

Paul K Sue; Grzegorz T Gurda; Richard Lee; Tonya Watkins; Rachel Green; Warda Memon; Aaron M Milstone; Adrian M Zelazny; Gary A Fahle; Thu Anh Pham; Connie F Gibas; Deanna A Sutton; Brian L Wickes; Nathan P Wiederhold; Sean X Zhang

doi:10.1128/JCM.02012-14

First report of Westerdykella dispersa as a cause of an angioinvasive fungal infection in a neutropenic host

J Clin Microbiol. 2014 Dec;52(12):4407-11. doi: 10.1128/JCM.02012-14. Epub 2014 Sep 17.

Authors

Affiliations

¹ Division of Pediatric Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Division of Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Microbiology Laboratory, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
⁴ Microbiology Service, Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland, USA.
⁵ Molecular Diagnostics Unit, Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland, USA.
⁶ University of Alberta Microfungus Collection and Herbarium, Edmonton, AB, Canada.
⁷ Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas, USA.
⁸ Division of Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Microbiology Laboratory, The Johns Hopkins Hospital, Baltimore, Maryland, USA szhang28@jhmi.edu.

Abstract

Angioinvasive fungal infections (AFIs) are an important cause of morbidity and mortality among immunocompromised patients. However, clinicomicrobiological characteristics and treatment of many AFI agents remain poorly defined. We report the first human case of infection with Westerdykella dispersa, an emergent cause of AFI, which was successfully treated in a neutropenic pediatric patient.

Publication types

Case Reports

MeSH terms

Ascomycota / classification
Ascomycota / genetics
Ascomycota / isolation & purification*
Child
DNA, Fungal / chemistry
DNA, Fungal / genetics
DNA, Ribosomal Spacer / chemistry
DNA, Ribosomal Spacer / genetics
Histocytochemistry
Humans
Immunocompromised Host
Injections / adverse effects
Male
Microbiological Techniques
Microscopy
Molecular Sequence Data
Mycoses / diagnosis*
Mycoses / microbiology
Mycoses / pathology*
Neutropenia / complications*
Radiography, Thoracic
Sequence Analysis, DNA
Tomography, X-Ray Computed
Vasculitis / diagnosis*
Vasculitis / microbiology
Vasculitis / pathology*

Substances

DNA, Fungal
DNA, Ribosomal Spacer

Associated data

GENBANK/KM008550
GENBANK/KM008551