Abstract
Cyclization-carbonylation of α,β-alkynic hydrazones and (o-alkynylphenyl) (methoxymethyl) sulfides with Pd(tfa)2 in DMSO/MeOH afforded methyl pyrazole-4-carboxylates and benzo[b]thiophene-3-carboxylates, respectively, in good yields. A simple change of the ligand (solvent) allowed controlled, effective switching between cyclization-carbonylation-cyclization-coupling (CCC-coupling) reactions and cyclization-carbonylation reactions.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Carboxylic Acids / chemical synthesis*
-
Catalysis
-
Cations, Divalent
-
Cyclization
-
Dimethyl Sulfoxide / chemistry
-
Hydrazones / chemistry*
-
Ligands
-
Methanol / chemistry
-
Palladium / chemistry*
-
Pyrazoles / chemical synthesis*
-
Thiophenes / chemical synthesis*
Substances
-
Carboxylic Acids
-
Cations, Divalent
-
Hydrazones
-
Ligands
-
Pyrazoles
-
Thiophenes
-
Palladium
-
Methanol
-
Dimethyl Sulfoxide