Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp

Arch Pharm Res. 2015 Jan;38(1):18-25. doi: 10.1007/s12272-014-0480-8. Epub 2014 Sep 19.

Abstract

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cholestadienols / isolation & purification*
  • Cholestadienols / pharmacology*
  • Cholestenes / isolation & purification*
  • Cholestenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Humans
  • Molecular Structure
  • Norsteroids / isolation & purification*
  • Norsteroids / pharmacology*
  • Porifera / chemistry*
  • Sterols / isolation & purification*
  • Sterols / pharmacology*
  • Sterols / toxicity

Substances

  • 5,8-epidioxy-24-norcholesta-6,9(11),22-trien-3-ol
  • 5,8-epidioxycholesta-6,23-dien-3,25-diol
  • Antineoplastic Agents
  • Cholestadienols
  • Cholestenes
  • Norsteroids
  • Sterols