Abstract
Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cholestadienols / isolation & purification*
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Cholestadienols / pharmacology*
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Cholestenes / isolation & purification*
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Cholestenes / pharmacology*
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Dose-Response Relationship, Drug
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Humans
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Molecular Structure
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Norsteroids / isolation & purification*
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Norsteroids / pharmacology*
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Porifera / chemistry*
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Sterols / isolation & purification*
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Sterols / pharmacology*
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Sterols / toxicity
Substances
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5,8-epidioxy-24-norcholesta-6,9(11),22-trien-3-ol
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5,8-epidioxycholesta-6,23-dien-3,25-diol
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Antineoplastic Agents
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Cholestadienols
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Cholestenes
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Norsteroids
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Sterols