Neutrophilic sebaceous adenitis with intralobular Demodex mites: a case report and review of the literature

Am J Dermatopathol. 2015 Apr;37(4):315-8. doi: 10.1097/DAD.0000000000000099.

Abstract

A 61-year-old white man presented with a 1-week history of an asymptomatic erythematous, annular plaque with minimal scale limited to the nasal bridge. Histological examination showed a mixed infiltrate of lymphocytes and neutrophils within sebaceous glands. The clinical and histopathological presentation was consistent with a diagnosis of neutrophilic sebaceous adenitis. Several Demodex brevis mites were present deep within the affected sebaceous lobules. Demodex brevis mites are uncommon inhabitants of sebaceous glands of the nose, presenting more commonly on other body sites. The cause of neutrophilic sebaceous adenitis is unknown, but the presence of D. brevis in affected sebaceous glands in this case suggests a possible association.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / therapeutic use
  • Biopsy
  • Facial Dermatoses / diagnosis
  • Facial Dermatoses / immunology
  • Facial Dermatoses / parasitology*
  • Humans
  • Male
  • Middle Aged
  • Mite Infestations / diagnosis
  • Mite Infestations / immunology
  • Mite Infestations / parasitology*
  • Mites / classification
  • Mites / immunology
  • Mites / pathogenicity*
  • Neutrophils / immunology
  • Neutrophils / parasitology*
  • Sebaceous Gland Diseases / diagnosis
  • Sebaceous Gland Diseases / immunology
  • Sebaceous Gland Diseases / parasitology*
  • Sebaceous Glands / immunology
  • Sebaceous Glands / parasitology*
  • Treatment Outcome

Substances

  • Anti-Infective Agents